Cellular metabolism1/20/2024 ![]() Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. The CASTOR proteins are arginine sensors for the mTORC1 pathway. Sestrin2 is a leucine sensor for the mTORC1 pathway. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. The dawn of the age of amino acid sensors for the mTORC1 pathway. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. This study shows that AKT promotes cell survival and growth in part by maintaining nutrient transporter levels on the plasma membrane. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Rheb binds and regulates the mTOR kinase. Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. mTOR signaling in growth, metabolism, and disease. Nutrient acquisition strategies of mammalian cells. (2017) provide the first evidence that lactate in the circulation can act as the major carbon source to fuel the TCA cycle in vivo. Glucose feeds the TCA cycle via circulating lactate. Understanding the Warburg effect: the metabolic requirements of cell proliferation. The emerging hallmarks of cancer metabolism. Discovery and saturation analysis of cancer genes across 21 tumour types. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. High frequency of mutations of the PIK3CA gene in human cancers. Treatment of HER2-positive breast cancer: current status and future perspectives. Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI? Nat. Recondo, G., Facchinetti, F., Olaussen, K. Mutational landscape and significance across 12 major cancer types. ![]() Fuel feeds function: energy metabolism and the T cell response. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. This work demonstrates that growth factor signalling is necessary for mammalian cells to maintain glucose uptake in support of bioenergetics and cell survival. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. CD28 costimulation: from mechanism to therapy. The CD28 signaling pathway regulates glucose metabolism. Insulin signalling and the regulation of glucose and lipid metabolism. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Wound healing-aiming for perfect skin regeneration. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Two-component systems and their co-option for eukaryotic signal transduction. On prokaryotic intelligence: strategies for sensing the environment. Transcriptional regulation in yeast during diauxic shift and stationary phase.
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